Two new papers in Nature and PLOS Genetics
(18-12-2020) Read about novel small-molecule inhibitors of the mitochondrial RNA polymerase, out in Nature. Also, we describe a high-throughput computational pipeline to detect mtDNA deletions and duplications, out in PLOS Genetics. Congrats to our lab members and collaborators!
Our chapter in the Methods in Molecular Biology book series is out
(14-12-2020) Our methods & protocols chapter describing the analysis of mtDNA replication using in vitro techniques is out now. Visist Mitochondrial Gene Expression – Methods in Molecular Biology.
Our latest review on mtDNA replication is out
(12-10-2020) Access our new review at Crit Rev Biochem Mol Biol. We present the latest developments in mammalian mtDNA replication, and also discuss the mechanisms behind how mtDNA deletions are formed.
(07-10-2020) Welcome back Dr. Layal Ishak, who returns to the group for several months. And we also welcome a new research assistant, Mãdãlina Sãcultanu.
Welcome Ulrika Alexandersson
(15-06-2020) We are pleased to have Ulrika Alexandersson join our group as a BMA.
Direnis passes her half-time PhD seminar
(24-04-2020) Direnis Erdinc, our ITN-Remix PhD fellow, passed a PhD milestone with an excellent half-time presentation to the evaluation committee. It was also the first time the rest of the group attended via zoom.
New review paper out
(14-04-2020) Visit Genes for our review paper on mitochondrial helicases. We mainly discuss TWINKLE structure and function and its role in mtDNA maintenance diseases. Also we review other reported mitochondrial helicases and discuss their potential roles in mitochondria.
(06-04-2020) We will be hiring postdocs! If you are interested, please send your CV to Jay Uhler.
(29-03-2020) Zofia Chrzanowska-Lightowlers and Robert Lightowlers from the Wellcome Trust Centre for Mitochondrial Research at Newcastle University were back in Gothenburg for a week of collaborative research in our lab. Also staying with us was Louis Debar from Geraldine Farge’s lab at the University of Clermont Auvergne.
National DNA Transactions Meeting
(29-01-2020) This year’s National DNA Transactions meeting in Stockholm saw many great talks, including from our very own postdoctoral research fellow, Örjan Persson.
First 2020 paper out
(05-01-2020) We characterized a novel POLG mutation in a patient with PEO, published in Neurology Genetics. The work is a collaboration with the Anders Oldfors and Erik Larsson Lekholm groups at GU.
Our lab profiled in GU Journal
(15-11-2019) Some great photos and interviews with some of our lab members and collaborators from the University of Newcastle. Article available in Swedish in the University´s magazine GU Journal (p. 24-28).
Cancerfonden awards 5.25 million SEK over three years
(14-11-2019) Many children treated for cancer develop complications later in life. Could damage to mtDNA be a contributing factor? This is a question Maria Falkenberg’s group will address with this funding from the Swedish Cancer Society, with the hope of finding new treatments with fewer side effects. Many news outlets are also excited about this project, including Swedish TV, Aftonbladet, and GT Expressen.
New paper on novel pathogenic mtSSB mutations
(30-09-2019) Bertil Macao from our group contributed to a multi-group collaboration led by the Carelli and Pippucci groups that identifies novel mtSSB mutations in patients with optic atrophy spectrum disorder.
Lab presentations at the Mitochondria in Human Disease Conference
(18-09-2019) A wonderful meeting with many highlights, with great presentations from Maria Falkenberg who talked about our latest work on mtSSB disease mutants, and Örjan Persson and Majda Mehmedovic who gave poster presentations about their mtDNA deletion and TFAM projects.
(29-08-2019) We have had a busy summer with four visiting scientists working in the lab. Dr. Layal Ishak came back from Lebanon to continue a project with us for a couple of months. From Newcastle, Professors Zofia Chrzanowska-Lightowlers and Robert Lightowlers have been with us for two weeks, along with their postdoc Shreya Ayyub, who is staying for a month. Always great having researchers wanting to come visit and collaborate with us!
New review paper out on how mtDNA is organized in mitochondria
(02-05-2019) Together with Geraldine Farge we review the role of TFAM in mtDNA compaction, and regulation of replication and transcription. Out now in the International Journal of Molecular Sciences – Organization of DNA in Mammalian Mitochondria.
Welcome Sebastian Valenzuela
(02-05-2019) We are happy to have Sebastian join as the group’s new research assistant.
Goodbye to Dzemila Secic
(01-04-2019) Time for Mila to move on from the lab because she is moving to Norrköping. All the best to her in her new BMA position there!
Maria Falkenberg becomes a Wallenberg Scholar
(25-03-2019) The Wallenberg Foundation announced today that Maria Falkenberg received a Wallenberg Scholars grant worth 18 million SEK over 5 years. Doubly good news because this makes Maria the first woman from the University of Gothenburg to receive this prestigious award. “We can start new, high risk projects that we otherwise wouldn’t dare to,” she said about the award (read more here).
Our latest paper is out in Nature Communications
(17-02-2019) We report on a new mechanism on how how mtDNA deletions arise: Copy-choice recombination during mitochondrial L-strand synthesis causes DNA deletions.
New year, new paper – out in PLoS Genetics
(07-01-2019) A new year all the happier with our latest paper – RNase H1 directs origin-specific initiation of DNA replication in human mitochondria.